Roles and subjects
Dr Sara Hope Browne Research Associate in Medical Sciences
Contact
Academic Background
I obtained my first degree in Molecular Biology (MBiolSci) at the University of Sheffield, during which time I spent a year in the pharmaceutical industry working on target validation in neurodegenerative disease. I completed my DPhil as part of the Interdisciplinary Bioscience Doctoral Training Programme at the University of Oxford, studying the effect of oxidative stress on RNA cargo loading into extracellular vesicles in a Drosophila model system. In 2021 I then moved to my current postdoctoral position in the Department of Clinical Neurosciences where I work on the neurodegenerative disease amyotrophic lateral sclerosis (ALS, also known as motor neuron disease; MND).
Research Interests
My research is focused on biomarker discovery for the neurodegenerative disease amyotrophic lateral sclerosis (ALS). This involves proteomic profiling of cerebrospinal fluid from patients and asymptomatic carriers of disease-causing C9orf72 mutation in ALS, with an additional focus on the use of biofluid-derived extracellular vesicles as potential source of biomarkers.
Publications
- Dellar, E.R., Hill, C., Carter, D.R.F., Baena-Lopez, L.A. (2024). Oxidative stress-induced changes in the transcriptomic profile of extracellular vesicles. Journal of Extracellular Biology 4, e150.
- Welsh, J.A., …. MISEV Consortium., et al. (2024). Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches. Journal of Extracellular Vesicles 13, e12404.
- Dellar, E.R., Vendrell, I., Talbot, K., Kessler, B., Fischer, R., Turner, M.R., Thompson, A.G. (2024). Data-independent acquisition proteomics of cerebrospinal fluid implicates endoplasmic reticulum and inflammatory mechanisms in amyotrophic lateral sclerosis. Journal of Neurochemistry 168, 115-127.
- Hill, C.*, Dellar, E.R.*, Baena-Lopez, L.A. (2023). Caspases help to spread the message via extracellular vesicles. The FEBS Journal 290, 1954-1972.
- Dellar, E.R., Hill. C., Melling, G.E., Carter, D.R.F., Baena-Lopez, L.A. (2022). Unpacking extracellular vesicles: RNA cargo loading and function. Journal of Extracellular Biology, e40.
- Melling, G.E., Conlon, R., Pantazi, P., Dellar, E.R., Samuel, P., Baena-Lopez, L.A., et al. (2022). Confocal microscopy analysis reveals that only a small proportion of extracellular vesicles are successfully labelled with commonly utilised staining methods. Scientific Reports 12, 1–13.
- Yates, A.G., Pink, R.C., Erdbrügger, U., R-M Siljander, P., Dellar, E.R., Pantazi, P., et al. (2022). In sickness and in health: The functional role of extracellular vesicles in physiology and pathology in vivo: Part I: Health and Normal Physiology. Journal of Extracellular Vesicles 11, e12151.
- Yates, A.G., Pink, R.C., Erdbrügger, U., R-M Siljander, P., Dellar, E.R., Pantazi, P., et al. (2022). In sickness and in health: The functional role of extracellular vesicles in physiology and pathology in vivo Part II: Pathology. Journal of Extracellular Vesicles 11, e12190.
Links
Subject notes for courses taught at Jesus College:
See also Dr Dellar’s Departmental profile and Medical School’s website.