MD, University of Basel, Switzerland, FMedSc
Hoffmann and Action Medical Research Professor of Developmental Medicine

Academic Background

Basel University Medical School, Switzerland (1977- 1984): training in Paediatrics and Paediatric Pulmonary Medicine at Harvard Medical School  and at Basel University Children’s Hospitals of Basel: training in Experimental Immunology at the Basel Institute for Immunology, Basel, Switzerland, and the Dana Farber Cancer Institute, Harvard Medical School, Boston, USA.

Undergraduate Teaching

Basic Immunology.

Postgraduate Teaching

T cell and developmental immunology: Primary Immunodeficiencies.

Research Interests

The molecular and cellular control of thymus development and function in health and disease.

Research Grants

Awarded July 2014: Wellcome Trust Strategic Award entitled 'The Homunculus in our Thymus: A Cellular Genomics Approach'.

Recent Publications

1)  Barthlott T, Bosch AJ, Berkemeier C, Nogales-Cadenas R, Jeker LT, Keller MP, Pascual-Montano A, and  Holländer GA. A subpopulation of CD103(pos) ICOS(pos) Treg cells occurs at high frequency in lymphopenic mice and represents a lymph node specific differentiation stage. Eur J Immunol. 2015;45:1760-71.
2)  Dertschnig S, Hauri-Hohl MM, Holländer GA, and Krenger W. Impaired thymic expression of tissue-restricted antigens licenses the de novo generation of autoreactive CD4+ T cells during murine acute GVHD. Blood. 2015;125:2720-3. *=shared senior authorship
3)  Salio M, Puleston DJ, Mathan TSM, Shepherd D, Stranks AJ, Adamopoulou E,  Veerapen N, Besra GS, Hollander GA, Simon AK and Cerundolo V. Essential role for autophagy during invariant NKT cell development. Proc Natl Acad Sci 2014 Dec 30;111(52):E5678-87. doi: 10.1073/pnas.1413935112
4)  Parkinson NJ, Roddis M, Ferneyhough B, Zhang G, Marsden AJ, Maslau S, Sanchez-Pearson Y, Barthlott T, Humphreys IR, Ladell K, Price DA, Ponting CP, Hollander GA, Fischer MD. Violation of the 12/23 rule of genomic V(D)J recombination is common in lymphocytes. Genome Res. 2014 Nov 3. pii: gr.179770.114
5)  Sansom SN, Shikama N, Zhanybekova S, Nusspaumer G, Macaulay IC, Deadman ME, Heger A, Ponting CP, Holländer GA. Population and single cell genomics reveal the Aire-dependency, relief from Polycomb silencing and distribution of self-antigen expression in thymic epithelia. Genome Res. 2014 Sep 15. pii: gr.171645.113. doi:10.1101/gr.171645.113
6) Kumar L, Chou J, Yee CS, Borzutzky A, Vollmann EH, von Andrian UH, Park SY, Hollander GA, Manis JP, Poliani PL, Geha RS. Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function. J Exp Med. 2014 May 5;211(5):929-42. doi: 10.1084/jem.20131379.
7)  Hauri-Hohl M, Zuklys S, Holländer GA, Ziegler SF. A regulatory role for TGF?-signaling in the establishment and function of the thymic medulla. Nature Immunol. 2014 Jun; 15(6):554-61. doi: 10.1038/ni.2869
8)  Mayer CE, Žuklys S, Zhanybekova S, Ohigashi I, Teh HY, Sansom SN, Shikama-Dorn N, Hafen K, Macaulay IC, Deadman ME, Ponting CP, Takahama Y, Holländer GA. Dynamic spatio-temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla. Eur J Immunol. 2016, 46:846-56
9)  Saldaña JI, Solanki A, Lau CI, Sahni H, Ross S, Furmanski AL, Ono M, Holländer G, Crompton T. Sonic Hedgehog regulates thymic epithelial cell differentiation. J Autoimmun. 2016, ;68:86-97
10)  Satoh R, Kakugawa K, Yasuda T, Yoshida H, Sibilia M, Katsura Y, Levi B, Abramson J, Koseki Y, Koseki H, van Ewijk W, Hollander GA, Kawamoto H. Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells. PLoS Genet. 2016, 12:e1005776.
11)  Ohigashi I, Zuklys S, Sakata M, Mayer CE, Hamazaki Y, Minato N, Hollander GA, Takahama Y.Adult Thymic Medullary Epithelium Is Maintained and Regenerated by Lineage-Restricted Cells Rather Than Bipotent Progenitors. Cell Rep. 2015 13:1432-43.
12)  Simon AK, Hollander GA, McMichael A. Evolution of the immune system in humans from infancy to old age. Proc Biol Sci. 2015, 282:20143085.
13)  Dertschnig, S, Hauri-Hohl MM, Vollmer M, Holländer* GA, Krenger* W. Impaired thymic expression of tissue-restricted antigens licenses the de novo generation of autoreactive CD4+ T cells during murine acute GVHD. Blood 2015, [125:2720-3. *=shared senior authorship]
14)  Žuklys s, Handel A, Zhanybekova S, Govani F, Keller M, Maio S, Mayer CE, The HY, Hafen K, Gallone G, Barthlott T, Ponting CP and Holländer GA. Foxn1 regulates in postnatal thymic epithelial cells key target genes essential for T cell development. Nature Immunology; 2016 [forthcoming]

Links

Subject notes for courses taught at Jesus College: Medicine

See also the Department of Paediatrics website and Professor Holländer's personal web page.